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2008


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Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia

(J. Neural Engineering Highlights of 2008 Collection)

Kim, S., Simeral, J., Hochberg, L., Donoghue, J. P., Black, M. J.

J. Neural Engineering, 5, pages: 455–476, 2008 (article)

Abstract
Computer-mediated connections between human motor cortical neurons and assistive devices promise to improve or restore lost function in people with paralysis. Recently, a pilot clinical study of an intracortical neural interface system demonstrated that a tetraplegic human was able to obtain continuous two-dimensional control of a computer cursor using neural activity recorded from his motor cortex. This control, however, was not sufficiently accurate for reliable use in many common computer control tasks. Here, we studied several central design choices for such a system including the kinematic representation for cursor movement, the decoding method that translates neuronal ensemble spiking activity into a control signal and the cursor control task used during training for optimizing the parameters of the decoding method. In two tetraplegic participants, we found that controlling a cursor’s velocity resulted in more accurate closed-loop control than controlling its position directly and that cursor velocity control was achieved more rapidly than position control. Control quality was further improved over conventional linear filters by using a probabilistic method, the Kalman filter, to decode human motor cortical activity. Performance assessment based on standard metrics used for the evaluation of a wide range of pointing devices demonstrated significantly improved cursor control with velocity rather than position decoding.

pdf preprint pdf from publisher [BibTex]

2008

pdf preprint pdf from publisher [BibTex]


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Incremental nonparametric Bayesian regression

Wood, F., Grollman, D. H., Heller, K. A., Jenkins, O. C., Black, M. J.

(CS-08-07), Brown University, Department of Computer Science, 2008 (techreport)

pdf [BibTex]

pdf [BibTex]


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Brownian Warps for Non-Rigid Registration

Mads Nielsen, Peter Johansen, Andrew Jackson, Benny Lautrup, Soren Hauberg

Journal of Mathematical Imaging and Vision, 31, pages: 221-231, Springer Netherlands, 2008 (article)

Publishers site PDF [BibTex]

Publishers site PDF [BibTex]


Thumb xl thumb screen shot 2012 10 06 at 12.28.24 pm
Simultaneous Visual Recognition of Manipulation Actions and Manipulated Objects

Kjellström, H., Romero, J., Martinez, D., Kragic, D.

In European Conference on Computer Vision, ECCV, pages: 336-349, 2008 (inproceedings)

Pdf [BibTex]

Pdf [BibTex]


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Tuning analysis of motor cortical neurons in a person with paralysis during performance of visually instructed cursor control tasks

Kim, S., Simeral, J. D., Hochberg, L. R., Truccolo, W., Donoghue, J., Friehs, G. M., Black, M. J.

2008 Abstract Viewer and Itinerary Planner, Society for Neuroscience, Washington, DC, 2008, Online (conference)

[BibTex]

[BibTex]


Thumb xl screen shot 2012 06 06 at 11.28.04 am
Infinite Kernel Learning

Gehler, P., Nowozin, S.

In Proceedings of NIPS 2008 Workshop on "Kernel Learning: Automatic Selection of Optimal Kernels", 2008 (inproceedings)

project page pdf [BibTex]

project page pdf [BibTex]


Thumb xl jmiv08theater
An Efficient Algorithm for Modelling Duration in Hidden Markov Models, with a Dramatic Application

Soren Hauberg, Jakob Sloth

Journal of Mathematical Imaging and Vision, 31, pages: 165-170, Springer Netherlands, 2008 (article)

Publishers site Paper site PDF [BibTex]

Publishers site Paper site PDF [BibTex]


Thumb xl thumb screen shot 2012 10 06 at 12.29.08 pm
Visual Recognition of Grasps for Human-to-Robot Mapping

Kjellström, H., Romero, J., Kragic, D.

In IEEE/RSJ International Conference on Intelligent Robots and Systems, IROS, pages: 3192-3199, 2008 (inproceedings)

Pdf [BibTex]

Pdf [BibTex]


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More than two years of intracortically-based cursor control via a neural interface system

Hochberg, L. R., Simeral, J. D., Kim, S., Stein, J., Friehs, G. M., Black, M. J., Donoghue, J. P.

2008 Abstract Viewer and Itinerary Planner, Society for Neuroscience, Washington, DC, 2008, Online (conference)

[BibTex]

[BibTex]


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Decoding of reach and grasp from MI population spiking activity using a low-dimensional model of hand and arm posture

Yadollahpour, P., Shakhnarovich, G., Vargas-Irwin, C., Donoghue, J. P., Black, M. J.

2008 Abstract Viewer and Itinerary Planner, Society for Neuroscience, Washington, DC, 2008, Online (conference)

[BibTex]

[BibTex]


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Neural activity in the motor cortex of humans with tetraplegia

Donoghue, J., Simeral, J., Black, M., Kim, S., Truccolo, W., Hochberg, L.

AREADNE Research in Encoding And Decoding of Neural Ensembles, June, Santorini, Greece, 2008 (conference)

[BibTex]

[BibTex]


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Nonrigid Structure from Motion in Trajectory Space

Akhter, I., Sheikh, Y., Khan, S., Kanade, T.

In Neural Information Processing Systems, 1(2):41-48, 2008 (inproceedings)

Abstract
Existing approaches to nonrigid structure from motion assume that the instantaneous 3D shape of a deforming object is a linear combination of basis shapes, which have to be estimated anew for each video sequence. In contrast, we propose that the evolving 3D structure be described by a linear combination of basis trajectories. The principal advantage of this approach is that we do not need to estimate any basis vectors during computation. We show that generic bases over trajectories, such as the Discrete Cosine Transform (DCT) basis, can be used to compactly describe most real motions. This results in a significant reduction in unknowns, and corresponding stability in estimation. We report empirical performance, quantitatively using motion capture data, and qualitatively on several video sequences exhibiting nonrigid motions including piece-wise rigid motion, partially nonrigid motion (such as a facial expression), and highly nonrigid motion (such as a person dancing).

pdf project page [BibTex]

pdf project page [BibTex]


Thumb xl sigalnips
Combined discriminative and generative articulated pose and non-rigid shape estimation

Sigal, L., Balan, A., Black, M. J.

In Advances in Neural Information Processing Systems 20, NIPS-2007, pages: 1337–1344, MIT Press, 2008 (inproceedings)

pdf [BibTex]

pdf [BibTex]


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Reconstructing reach and grasp actions using neural population activity from Primary Motor Cortex

Vargas-Irwin, C. E., Yadollahpour, P., Shakhnarovich, G., Black, M. J., Donoghue, J. P.

2008 Abstract Viewer and Itinerary Planner, Society for Neuroscience, Washington, DC, 2008, Online (conference)

[BibTex]

[BibTex]

2007


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A Database and Evaluation Methodology for Optical Flow

Baker, S., Scharstein, D., Lewis, J.P., Roth, S., Black, M.J., Szeliski, R.

In Int. Conf. on Computer Vision, ICCV, pages: 1-8, Rio de Janeiro, Brazil, October 2007 (inproceedings)

pdf [BibTex]

2007

pdf [BibTex]


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Shining a light on human pose: On shadows, shading and the estimation of pose and shape,

Balan, A., Black, M. J., Haussecker, H., Sigal, L.

In Int. Conf. on Computer Vision, ICCV, pages: 1-8, Rio de Janeiro, Brazil, October 2007 (inproceedings)

pdf YouTube [BibTex]

pdf YouTube [BibTex]


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Ensemble spiking activity as a source of cortical control signals in individuals with tetraplegia

Simeral, J. D., Kim, S. P., Black, M. J., Donoghue, J. P., Hochberg, L. R.

Biomedical Engineering Society, BMES, september 2007 (conference)

[BibTex]

[BibTex]


Thumb xl cvpr07scape
Detailed human shape and pose from images

Balan, A., Sigal, L., Black, M. J., Davis, J., Haussecker, H.

In IEEE Conf. on Computer Vision and Pattern Recognition, CVPR, pages: 1-8, Minneapolis, June 2007 (inproceedings)

Abstract
Much of the research on video-based human motion capture assumes the body shape is known a priori and is represented coarsely (e.g. using cylinders or superquadrics to model limbs). These body models stand in sharp contrast to the richly detailed 3D body models used by the graphics community. Here we propose a method for recovering such models directly from images. Specifically, we represent the body using a recently proposed triangulated mesh model called SCAPE which employs a low-dimensional, but detailed, parametric model of shape and pose-dependent deformations that is learned from a database of range scans of human bodies. Previous work showed that the parameters of the SCAPE model could be estimated from marker-based motion capture data. Here we go further to estimate the parameters directly from image data. We define a cost function between image observations and a hypothesized mesh and formulate the problem as optimization over the body shape and pose parameters using stochastic search. Our results show that such rich generative models enable the automatic recovery of detailed human shape and pose from images.

pdf YouTube [BibTex]

pdf YouTube [BibTex]


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Learning static Gestalt laws through dynamic experience

Ostrovsky, Y., Wulff, J., Sinha, P.

Journal of Vision, 7(9):315-315, ARVO, June 2007 (article)

Abstract
The Gestalt laws (Wertheimer 1923) are widely regarded as the rules that help us parse the world into objects. However, it is unclear as to how these laws are acquired by an infant's visual system. Classically, these “laws” have been presumed to be innate (Kellman and Spelke 1983). But, more recent work in infant development, showing the protracted time-course over which these grouping principles emerge (e.g., Johnson and Aslin 1995; Craton 1996), suggests that visual experience might play a role in their genesis. Specifically, our studies of patients with late-onset vision (Project Prakash; VSS 2006) and evidence from infant development both point to an early role of common motion cues for object grouping. Here we explore the possibility that the privileged status of motion in the developmental timeline is not happenstance, but rather serves to bootstrap the learning of static Gestalt cues. Our approach involves computational analyses of real-world motion sequences to investigate whether primitive optic flow information is correlated with static figural cues that could eventually come to serve as proxies for grouping in the form of Gestalt principles. We calculated local optic flow maps and then examined how similarity of motion across image patches co-varied with similarity of certain figural properties in static frames. Results indicate that patches with similar motion are much more likely to have similar luminance, color, and orientation as compared to patches with dissimilar motion vectors. This regularity suggests that, in principle, common motion extracted from dynamic visual experience can provide enough information to bootstrap region grouping based on luminance and color and contour continuation mechanisms in static scenes. These observations, coupled with the cited experimental studies, lend credence to the hypothesis that static Gestalt laws might be learned through a bootstrapping process based on early dynamic experience.

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Decoding grasp aperture from motor-cortical population activity

Artemiadis, P., Shakhnarovich, G., Vargas-Irwin, C., Donoghue, J. P., Black, M. J.

In The 3rd International IEEE EMBS Conference on Neural Engineering, pages: 518-521, May 2007 (inproceedings)

pdf [BibTex]

pdf [BibTex]


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Multi-state decoding of point-and-click control signals from motor cortical activity in a human with tetraplegia

Kim, S., Simeral, J., Hochberg, L., Donoghue, J. P., Friehs, G., Black, M. J.

In The 3rd International IEEE EMBS Conference on Neural Engineering, pages: 486-489, May 2007 (inproceedings)

Abstract
Basic neural-prosthetic control of a computer cursor has been recently demonstrated by Hochberg et al. [1] using the BrainGate system (Cyberkinetics Neurotechnology Systems, Inc.). While these results demonstrate the feasibility of intracortically-driven prostheses for humans with paralysis, a practical cursor-based computer interface requires more precise cursor control and the ability to “click” on areas of interest. Here we present a practical point and click device that decodes both continuous states (e.g. cursor kinematics) and discrete states (e.g. click state) from single neural population in human motor cortex. We describe a probabilistic multi-state decoder and the necessary training paradigms that enable point and click cursor control by a human with tetraplegia using an implanted microelectrode array. We present results from multiple recording sessions and quantify the point and click performance.

pdf [BibTex]

pdf [BibTex]


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Neuromotor prosthesis development

Donoghue, J., Hochberg, L., Nurmikko, A., Black, M., Simeral, J., Friehs, G.

Medicine & Health Rhode Island, 90(1):12-15, January 2007 (article)

Abstract
Article describes a neuromotor prosthesis (NMP), in development at Brown University, that records human brain signals, decodes them, and transforms them into movement commands. An NMP is described as a system consisting of a neural interface, a decoding system, and a user interface, also called an effector; a closed-loop system would be completed by a feedback signal from the effector to the brain. The interface is based on neural spiking, a source of information-rich, rapid, complex control signals from the nervous system. The NMP described, named BrainGate, consists of a match-head sized platform with 100 thread-thin electrodes implanted just into the surface of the motor cortex where commands to move the hand emanate. Neural signals are decoded by a rack of computers that displays the resultant output as the motion of a cursor on a computer monitor. While computer cursor motion represents a form of virtual device control, this same command signal could be routed to a device to command motion of paralyzed muscles or the actions of prosthetic limbs. The researchers’ overall goal is the development of a fully implantable, wireless multi-neuron sensor for broad research, neural prosthetic, and human neurodiagnostic applications.

pdf [BibTex]

pdf [BibTex]


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On the spatial statistics of optical flow

Roth, S., Black, M. J.

International Journal of Computer Vision, 74(1):33-50, 2007 (article)

Abstract
We present an analysis of the spatial and temporal statistics of "natural" optical flow fields and a novel flow algorithm that exploits their spatial statistics. Training flow fields are constructed using range images of natural scenes and 3D camera motions recovered from hand-held and car-mounted video sequences. A detailed analysis of optical flow statistics in natural scenes is presented and machine learning methods are developed to learn a Markov random field model of optical flow. The prior probability of a flow field is formulated as a Field-of-Experts model that captures the spatial statistics in overlapping patches and is trained using contrastive divergence. This new optical flow prior is compared with previous robust priors and is incorporated into a recent, accurate algorithm for dense optical flow computation. Experiments with natural and synthetic sequences illustrate how the learned optical flow prior quantitatively improves flow accuracy and how it captures the rich spatial structure found in natural scene motion.

pdf preprint pdf from publisher [BibTex]

pdf preprint pdf from publisher [BibTex]


Thumb xl screen shot 2012 06 06 at 11.20.23 am
Deterministic Annealing for Multiple-Instance Learning

Gehler, P., Chapelle, O.

In Artificial Intelligence and Statistics (AIStats), 2007 (inproceedings)

pdf [BibTex]

pdf [BibTex]


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Point-and-click cursor control by a person with tetraplegia using an intracortical neural interface system

Kim, S., Simeral, J. D., Hochberg, L. R., Friehs, G., Donoghue, J. P., Black, M. J.

Program No. 517.2. 2007 Abstract Viewer and Itinerary Planner, Society for Neuroscience, San Diego, CA, 2007, Online (conference)

[BibTex]

[BibTex]


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Assistive technology and robotic control using MI ensemble-based neural interface systems in humans with tetraplegia

Donoghue, J. P., Nurmikko, A., Black, M. J., Hochberg, L.

Journal of Physiology, Special Issue on Brain Computer Interfaces, 579, pages: 603-611, 2007 (article)

Abstract
This review describes the rationale, early stage development, and initial human application of neural interface systems (NISs) for humans with paralysis. NISs are emerging medical devices designed to allowpersonswith paralysis to operate assistive technologies or to reanimatemuscles based upon a command signal that is obtained directly fromthe brain. Such systems require the development of sensors to detect brain signals, decoders to transformneural activity signals into a useful command, and an interface for the user.We review initial pilot trial results of an NIS that is based on an intracortical microelectrode sensor that derives control signals from the motor cortex.We review recent findings showing, first, that neurons engaged by movement intentions persist in motor cortex years after injury or disease to the motor system, and second, that signals derived from motor cortex can be used by persons with paralysis to operate a range of devices. We suggest that, with further development, this form of NIS holds promise as a useful new neurotechnology for those with limited motor function or communication.We also discuss the additional potential for neural sensors to be used in the diagnosis and management of various neurological conditions and as a new way to learn about human brain function.

pdf preprint pdf from publisher DOI [BibTex]

pdf preprint pdf from publisher DOI [BibTex]


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Probabilistically modeling and decoding neural population activity in motor cortex

Black, M. J., Donoghue, J. P.

In Toward Brain-Computer Interfacing, pages: 147-159, (Editors: Dornhege, G. and del R. Millan, J. and Hinterberger, T. and McFarland, D. and Muller, K.-R.), MIT Press, London, 2007 (incollection)

pdf [BibTex]

pdf [BibTex]


Thumb xl screen shot 2012 02 23 at 1.59.51 pm
Learning Appearances with Low-Rank SVM

Wolf, L., Jhuang, H., Hazan, T.

In Conference on Computer Vision and Pattern Recognition (CVPR), 2007 (inproceedings)

pdf [BibTex]

pdf [BibTex]


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Neural correlates of grip aperture in primary motor cortex

Vargas-Irwin, C., Shakhnarovich, G., Artemiadis, P., Donoghue, J. P., Black, M. J.

Program No. 517.10. 2007 Abstract Viewer and Itinerary Planner, Society for Neuroscience, San Diego, CA, 2007, Online (conference)

[BibTex]

[BibTex]


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Directional tuning in motor cortex of a person with ALS

Simeral, J. D., Donoghue, J. P., Black, M. J., Friehs, G. M., Brown, R. H., Krivickas, L. S., Hochberg, L. R.

Program No. 517.4. 2007 Abstract Viewer and Itinerary Planner, Society for Neuroscience, San Diego, CA, 2007, Online (conference)

[BibTex]

[BibTex]


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Denoising archival films using a learned Bayesian model

Moldovan, T. M., Roth, S., Black, M. J.

(CS-07-03), Brown University, Department of Computer Science, 2007 (techreport)

pdf [BibTex]

pdf [BibTex]


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Steerable random fields

(Best Paper Award, INI-Graphics Net, 2008)

Roth, S., Black, M. J.

In Int. Conf. on Computer Vision, ICCV, pages: 1-8, Rio de Janeiro, Brazil, 2007 (inproceedings)

pdf [BibTex]

pdf [BibTex]


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Toward standardized assessment of pointing devices for brain-computer interfaces

Donoghue, J., Simeral, J., Kim, S., G.M. Friehs, L. H., Black, M.

Program No. 517.16. 2007 Abstract Viewer and Itinerary Planner, Society for Neuroscience, San Diego, CA, 2007, Online (conference)

[BibTex]

[BibTex]


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A Biologically Inspired System for Action Recognition

Jhuang, H., Serre, T., Wolf, L., Poggio, T.

In International Conference on Computer Vision (ICCV), 2007 (inproceedings)

code pdf [BibTex]

code pdf [BibTex]


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AREADNE Research in Encoding And Decoding of Neural Ensembles

Shakhnarovich, G., Hochberg, L. R., Donoghue, J. P., Stein, J., Brown, R. H., Krivickas, L. S., Friehs, G. M., Black, M. J.

Program No. 517.8. 2007 Abstract Viewer and Itinerary Planner, Society for Neuroscience, San Diego, CA, 2007, Online (conference)

[BibTex]

[BibTex]

2005


Thumb xl ivc05
Representing cyclic human motion using functional analysis

Ormoneit, D., Black, M. J., Hastie, T., Kjellström, H.

Image and Vision Computing, 23(14):1264-1276, December 2005 (article)

Abstract
We present a robust automatic method for modeling cyclic 3D human motion such as walking using motion-capture data. The pose of the body is represented by a time-series of joint angles which are automatically segmented into a sequence of motion cycles. The mean and the principal components of these cycles are computed using a new algorithm that enforces smooth transitions between the cycles by operating in the Fourier domain. Key to this method is its ability to automatically deal with noise and missing data. A learned walking model is then exploited for Bayesian tracking of 3D human motion.

pdf pdf from publisher DOI [BibTex]

2005

pdf pdf from publisher DOI [BibTex]


Thumb xl pets 2005 copy
A quantitative evaluation of video-based 3D person tracking

Balan, A. O., Sigal, L., Black, M. J.

In The Second Joint IEEE International Workshop on Visual Surveillance and Performance Evaluation of Tracking and Surveillance, VS-PETS, pages: 349-356, October 2005 (inproceedings)

pdf [BibTex]

pdf [BibTex]


Thumb xl embs05
Inferring attentional state and kinematics from motor cortical firing rates

Wood, F., Prabhat, , Donoghue, J. P., Black, M. J.

In Proc. IEEE Engineering in Medicine and Biology Society, pages: 1544-1547, September 2005 (inproceedings)

pdf [BibTex]

pdf [BibTex]


Thumb xl arma
Motor cortical decoding using an autoregressive moving average model

Fisher, J., Black, M. J.

In Proc. IEEE Engineering in Medicine and Biology Society, pages: 1469-1472, September 2005 (inproceedings)

pdf [BibTex]

pdf [BibTex]


Thumb xl cvpr2005
Fields of Experts: A framework for learning image priors

Roth, S., Black, M. J.

In IEEE Conf. on Computer Vision and Pattern Recognition, 2, pages: 860-867, June 2005 (inproceedings)

pdf [BibTex]

pdf [BibTex]


Thumb xl picture for seq 15 stabilization
A Flow-Based Approach to Vehicle Detection and Background Mosaicking in Airborne Video

Yalcin, H. C. R. B. M. J. H. M.

IEEE Conf. on Computer Vision and Pattern Recognition (CVPR), Video Proceedings,, pages: 1202, 2005 (patent)

YouTube pdf [BibTex]

YouTube pdf [BibTex]


Thumb xl iccv05roth
On the spatial statistics of optical flow

(Marr Prize, Honorable Mention)

Roth, S., Black, M. J.

In International Conf. on Computer Vision, International Conf. on Computer Vision, pages: 42-49, 2005 (inproceedings)

pdf [BibTex]

pdf [BibTex]


Thumb xl nips05
Modeling neural population spiking activity with Gibbs distributions

Wood, F., Roth, S., Black, M. J.

In Advances in Neural Information Processing Systems 18, pages: 1537-1544, 2005 (inproceedings)

pdf [BibTex]

pdf [BibTex]


no image
Energy-based models of motor cortical population activity

Wood, F., Black, M.

Program No. 689.20. 2005 Abstract Viewer/Itinerary Planner, Society for Neuroscience, Washington, DC, 2005 (conference)

abstract [BibTex]

abstract [BibTex]

2002


Thumb xl bildschirmfoto 2013 01 15 um 09.54.19
Inferring hand motion from multi-cell recordings in motor cortex using a Kalman filter

Wu, W., Black, M. J., Gao, Y., Bienenstock, E., Serruya, M., Donoghue, J. P.

In SAB’02-Workshop on Motor Control in Humans and Robots: On the Interplay of Real Brains and Artificial Devices, pages: 66-73, Edinburgh, Scotland (UK), August 2002 (inproceedings)

pdf [BibTex]

2002

pdf [BibTex]


Thumb xl bildschirmfoto 2013 01 15 um 10.33.56
Bayesian Inference of Visual Motion Boundaries

Fleet, D. J., Black, M. J., Nestares, O.

In Exploring Artificial Intelligence in the New Millennium, pages: 139-174, (Editors: Lakemeyer, G. and Nebel, B.), Morgan Kaufmann Pub., July 2002 (incollection)

Abstract
This chapter addresses an open problem in visual motion analysis, the estimation of image motion in the vicinity of occlusion boundaries. With a Bayesian formulation, local image motion is explained in terms of multiple, competing, nonlinear models, including models for smooth (translational) motion and for motion boundaries. The generative model for motion boundaries explicitly encodes the orientation of the boundary, the velocities on either side, the motion of the occluding edge over time, and the appearance/disappearance of pixels at the boundary. We formulate the posterior probability distribution over the models and model parameters, conditioned on the image sequence. Approximate inference is achieved with a combination of tools: A Bayesian filter provides for online computation; factored sampling allows us to represent multimodal non-Gaussian distributions and to propagate beliefs with nonlinear dynamics from one time to the next; and mixture models are used to simplify the computation of joint prediction distributions in the Bayesian filter. To efficiently represent such a high-dimensional space, we also initialize samples using the responses of a low-level motion-discontinuity detector. The basic formulation and computational model provide a general probabilistic framework for motion estimation with multiple, nonlinear models.

pdf [BibTex]

pdf [BibTex]


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Inferring hand motion from multi-cell recordings in motor cortex using a Kalman filter

Wu, W., Black M., Gao, Y., Bienenstock, E., Serruya, M., Donoghue, J.

Program No. 357.5. 2002 Abstract Viewer/Itinerary Planner, Society for Neuroscience, Washington, DC, 2002, Online (conference)

abstract [BibTex]

abstract [BibTex]


Thumb xl bildschirmfoto 2013 01 15 um 10.03.10
Probabilistic inference of hand motion from neural activity in motor cortex

Gao, Y., Black, M. J., Bienenstock, E., Shoham, S., Donoghue, J.

In Advances in Neural Information Processing Systems 14, pages: 221-228, MIT Press, 2002 (inproceedings)

Abstract
Statistical learning and probabilistic inference techniques are used to infer the hand position of a subject from multi-electrode recordings of neural activity in motor cortex. First, an array of electrodes provides train- ing data of neural firing conditioned on hand kinematics. We learn a non- parametric representation of this firing activity using a Bayesian model and rigorously compare it with previous models using cross-validation. Second, we infer a posterior probability distribution over hand motion conditioned on a sequence of neural test data using Bayesian inference. The learned firing models of multiple cells are used to define a non- Gaussian likelihood term which is combined with a prior probability for the kinematics. A particle filtering method is used to represent, update, and propagate the posterior distribution over time. The approach is com- pared with traditional linear filtering methods; the results suggest that it may be appropriate for neural prosthetic applications.

pdf [BibTex]

pdf [BibTex]